Involvement of Ca(2+)-activated K(+) channel 3.1 in hypoxia-induced pulmonary arterial hypertension and therapeutic effects of TRAM-34 in rats

Pulmonary artery hypertension (PAH) is an incurable disease associated with the proliferation of pulmonary artery smooth muscle cells (PASMCs) and vascular remodeling. The present study examined whether TRAM-34, a highly selective blocker of calcium-activated potassium channel 3.1 (Kca3.1), can help...

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Podrobná bibliografie
Vydáno v:Biosci Rep
Hlavní autoři: Guo, Shujin, Shen, Yongchun, He, Guangming, Wang, Tao, Xu, Dan, Wen, Fuqiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529208/
https://ncbi.nlm.nih.gov/pubmed/28679649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20170763
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