Topoisomerase‐1 and ‐2A gene copy numbers are elevated in mismatch repair‐proficient colorectal cancers

INTRODUCTION: Topoisomerase 1 (TOP1) and 2A (TOP2A) are potential predictive biomarkers for irinotecan and anthracycline treatment, respectively, in colorectal cancer (CRC), and we have recently reported a high frequency of gene gain of the TOP1 and TOP2A genes in CRC. Furthermore, Mismatch Repair (...

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Détails bibliographiques
Publié dans:Mol Oncol
Auteurs principaux: Sønderstrup, Ida Marie Heeholm, Nygård, Sune Boris, Poulsen, Tim Svenstrup, Linnemann, Dorte, Stenvang, Jan, Nielsen, Hans Jørgen, Bartek, Jiri, Brünner, Nils, Nørgaard, Peter, Riis, Lene
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528751/
https://ncbi.nlm.nih.gov/pubmed/25777966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.02.009
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