Topoisomerase‐1 and ‐2A gene copy numbers are elevated in mismatch repair‐proficient colorectal cancers

INTRODUCTION: Topoisomerase 1 (TOP1) and 2A (TOP2A) are potential predictive biomarkers for irinotecan and anthracycline treatment, respectively, in colorectal cancer (CRC), and we have recently reported a high frequency of gene gain of the TOP1 and TOP2A genes in CRC. Furthermore, Mismatch Repair (...

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Publicado en:Mol Oncol
Autores principales: Sønderstrup, Ida Marie Heeholm, Nygård, Sune Boris, Poulsen, Tim Svenstrup, Linnemann, Dorte, Stenvang, Jan, Nielsen, Hans Jørgen, Bartek, Jiri, Brünner, Nils, Nørgaard, Peter, Riis, Lene
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2015
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528751/
https://ncbi.nlm.nih.gov/pubmed/25777966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.02.009
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