Topoisomerase I copy number alterations as biomarker for irinotecan efficacy in metastatic colorectal cancer

BACKGROUND: No biomarker exists to guide the optimal choice of chemotherapy for patients with metastatic colorectal cancer. We examined the copy numbers (CN) of topoisomerase I (TOP1) as well as the ratios of TOP1/CEN-20 and TOP1/CEN-2 as biomarkers for irinotecan efficacy in patients with metastati...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Palshof, Jesper Andreas, Høgdall, Estrid Vilma Solyom, Poulsen, Tim Svenstrup, Linnemann, Dorte, Jensen, Benny Vittrup, Pfeiffer, Per, Tarpgaard, Line Schmidt, Brünner, Nils, Stenvang, Jan, Yilmaz, Mette, Nielsen, Dorte Lisbet
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225543/
https://ncbi.nlm.nih.gov/pubmed/28077117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-3001-y
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