Implications of ABCG2 Expression on Irinotecan Treatment of Colorectal Cancer Patients: A Review

Background: One of the main chemotherapeutic drugs used on a routine basis in patients with metastatic colorectal cancer ((m)CRC) is the topoisomerase-1 inhibitor, irinotecan. However, its usefulness is limited by the pre-existing or inevitable development of resistance. The ATP-binding cassette (AB...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Autores principales: Nielsen, Dorte Lisbet, Palshof, Jesper Andreas, Brünner, Nils, Stenvang, Jan, Viuff, Birgitte Martine
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2017
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Review
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618575/
https://ncbi.nlm.nih.gov/pubmed/28880238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18091926
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