Untangling the ATR‐CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer

ATR‐CHEK1 signalling is critical for genomic stability. ATR‐CHEK1 signalling may be deregulated in breast cancer and have prognostic, predictive and therapeutic significance. We investigated ATR, CHEK1 and phosphorylated CHEK1 Ser345 protein (pCHEK1) levels in 1712 breast cancers. ATR and CHEK1 mRNA...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Abdel-Fatah, Tarek M.A., Middleton, Fiona K., Arora, Arvind, Agarwal, Devika, Chen, Tao, Moseley, Paul M., Perry, Christina, Doherty, Rachel, Chan, Stephen, Green, Andrew R., Rakha, Emad, Ball, Graham, Ellis, Ian O., Curtin, Nicola J., Madhusudan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528699/
https://ncbi.nlm.nih.gov/pubmed/25468710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.10.013
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