Untangling the ATR‐CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer

ATR‐CHEK1 signalling is critical for genomic stability. ATR‐CHEK1 signalling may be deregulated in breast cancer and have prognostic, predictive and therapeutic significance. We investigated ATR, CHEK1 and phosphorylated CHEK1 Ser345 protein (pCHEK1) levels in 1712 breast cancers. ATR and CHEK1 mRNA...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Oncol
Prif Awduron: Abdel-Fatah, Tarek M.A., Middleton, Fiona K., Arora, Arvind, Agarwal, Devika, Chen, Tao, Moseley, Paul M., Perry, Christina, Doherty, Rachel, Chan, Stephen, Green, Andrew R., Rakha, Emad, Ball, Graham, Ellis, Ian O., Curtin, Nicola J., Madhusudan, Srinivasan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2014
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528699/
https://ncbi.nlm.nih.gov/pubmed/25468710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.10.013
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