DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers

Stratification of oestrogen receptor (ER) negative and triple negative breast cancers (TNBCs) is urgently needed. In the current study, a cohort of 880 ER- (including 635 TNBCs) was immuno-profiled for a panel of DNA repair proteins including: Pol β, FEN1, APE1, XRCC1, SMUG1, PARP1, BRCA1, ATR, ATM,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Abdel-Fatah, Tarek M.A., Arora, Arvind, Moseley, Paul M., Perry, Christina, Rakha, Emad A., Green, Andrew R., Chan, Stephen Y.T., Ellis, Ian O., Madhusudan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673139/
https://ncbi.nlm.nih.gov/pubmed/26267318
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