Targeting BRCA1‐BER deficient breast cancer by ATM or DNA‐PKcs blockade either alone or in combination with cisplatin for personalized therapy

BRCA1, a key factor in homologous recombination (HR) repair may also regulate base excision repair (BER). Targeting BRCA1‐BER deficient cells by blockade of ATM and DNA‐PKcs could be a promising strategy in breast cancer. We investigated BRCA1, XRCC1 and pol β protein expression in two cohorts (n = ...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Albarakati, Nada, Abdel-Fatah, Tarek M.A., Doherty, Rachel, Russell, Roslin, Agarwal, Devika, Moseley, Paul, Perry, Christina, Arora, Arvind, Alsubhi, Nouf, Seedhouse, Claire, Rakha, Emad A., Green, Andrew, Ball, Graham, Chan, Stephen, Caldas, Carlos, Ellis, Ian O., Madhusudan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528668/
https://ncbi.nlm.nih.gov/pubmed/25205036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.08.001
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