Targeting BRCA1‐BER deficient breast cancer by ATM or DNA‐PKcs blockade either alone or in combination with cisplatin for personalized therapy

BRCA1, a key factor in homologous recombination (HR) repair may also regulate base excision repair (BER). Targeting BRCA1‐BER deficient cells by blockade of ATM and DNA‐PKcs could be a promising strategy in breast cancer. We investigated BRCA1, XRCC1 and pol β protein expression in two cohorts (n = ...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Albarakati, Nada, Abdel-Fatah, Tarek M.A., Doherty, Rachel, Russell, Roslin, Agarwal, Devika, Moseley, Paul, Perry, Christina, Arora, Arvind, Alsubhi, Nouf, Seedhouse, Claire, Rakha, Emad A., Green, Andrew, Ball, Graham, Chan, Stephen, Caldas, Carlos, Ellis, Ian O., Madhusudan, Srinivasan
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528668/
https://ncbi.nlm.nih.gov/pubmed/25205036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.08.001
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