Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma

Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss‐of‐function mutations in the tumor suppressor gene, PTCH1. PTCH1 normally functions by repressing the activity of the Smoothened (SMO) receptor. Inactivating PTCH1 mutations result in constitutive Hedgehog pathwa...

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發表在:Mol Oncol
Main Authors: Pricl, Sabrina, Cortelazzi, Barbara, Dal Col, Valentina, Marson, Domenico, Laurini, Erik, Fermeglia, Maurizio, Licitra, Lisa, Pilotti, Silvana, Bossi, Paolo, Perrone, Federica
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2014
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528667/
https://ncbi.nlm.nih.gov/pubmed/25306392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.09.003
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