Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma

Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss‐of‐function mutations in the tumor suppressor gene, PTCH1. PTCH1 normally functions by repressing the activity of the Smoothened (SMO) receptor. Inactivating PTCH1 mutations result in constitutive Hedgehog pathwa...

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Vydáno v:Mol Oncol
Hlavní autoři: Pricl, Sabrina, Cortelazzi, Barbara, Dal Col, Valentina, Marson, Domenico, Laurini, Erik, Fermeglia, Maurizio, Licitra, Lisa, Pilotti, Silvana, Bossi, Paolo, Perrone, Federica
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2014
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528667/
https://ncbi.nlm.nih.gov/pubmed/25306392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.09.003
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