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Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma
Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss‐of‐function mutations in the tumor suppressor gene, PTCH1. PTCH1 normally functions by repressing the activity of the Smoothened (SMO) receptor. Inactivating PTCH1 mutations result in constitutive Hedgehog pathwa...
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| Publicado no: | Mol Oncol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5528667/ https://ncbi.nlm.nih.gov/pubmed/25306392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.09.003 |
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