Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma

Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss‐of‐function mutations in the tumor suppressor gene, PTCH1. PTCH1 normally functions by repressing the activity of the Smoothened (SMO) receptor. Inactivating PTCH1 mutations result in constitutive Hedgehog pathwa...

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Publicat a:Mol Oncol
Autors principals: Pricl, Sabrina, Cortelazzi, Barbara, Dal Col, Valentina, Marson, Domenico, Laurini, Erik, Fermeglia, Maurizio, Licitra, Lisa, Pilotti, Silvana, Bossi, Paolo, Perrone, Federica
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528667/
https://ncbi.nlm.nih.gov/pubmed/25306392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.09.003
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