Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15‐dependent drug resistance

The mitotic kinesin KIF11 (also called Eg5) plays critical roles in spindle functions. Although a number of small‐molecule inhibitors of KIF11 are currently in clinical development, drug‐resistance could be developed through compensation by another kinesin called KIF15. Using a newly developed infra...

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Bibliografske podrobnosti
izdano v:Mol Oncol
Main Authors: Ma, Hoi Tang, Erdal, Sergio, Huang, Shan, Poon, Randy Y.C.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2014
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528592/
https://ncbi.nlm.nih.gov/pubmed/24950801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.05.007
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