The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells

About 20% of breast cancers are characterized by amplification and overexpression of the HER2 oncogene. Although significant progress has been achieved for treating such patients with HER2 inhibitor trastuzumab, more than half of the patients respond poorly or become resistant to the treatment. Sinc...

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Pubblicato in:Mol Oncol
Autori principali: Sahlberg, Kristine Kleivi, Hongisto, Vesa, Edgren, Henrik, Mäkelä, Rami, Hellström, Kirsi, Due, Eldri U., Moen Vollan, Hans Kristian, Sahlberg, Niko, Wolf, Maija, Børresen-Dale, Anne-Lise, Perälä, Merja, Kallioniemi, Olli
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2012
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528495/
https://ncbi.nlm.nih.gov/pubmed/23253899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.10.012
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