The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells

About 20% of breast cancers are characterized by amplification and overexpression of the HER2 oncogene. Although significant progress has been achieved for treating such patients with HER2 inhibitor trastuzumab, more than half of the patients respond poorly or become resistant to the treatment. Sinc...

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Detalles Bibliográficos
Publicado en:Mol Oncol
Main Authors: Sahlberg, Kristine Kleivi, Hongisto, Vesa, Edgren, Henrik, Mäkelä, Rami, Hellström, Kirsi, Due, Eldri U., Moen Vollan, Hans Kristian, Sahlberg, Niko, Wolf, Maija, Børresen-Dale, Anne-Lise, Perälä, Merja, Kallioniemi, Olli
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2012
Assuntos:
Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528495/
https://ncbi.nlm.nih.gov/pubmed/23253899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.10.012
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