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FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia
The adaptor protein Grb10 plays important roles in mitogenic signaling. However, its roles in acute myeloid leukemia (AML) are predominantly unknown. Here we describe the role of Grb10 in FLT3‐ITD‐mediated AML. We observed that Grb10 physically associates with FLT3 in response to FLT3‐ligand (FL) st...
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| Udgivet i: | Mol Oncol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5528487/ https://ncbi.nlm.nih.gov/pubmed/23246379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.11.003 |
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