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FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

The adaptor protein Grb10 plays important roles in mitogenic signaling. However, its roles in acute myeloid leukemia (AML) are predominantly unknown. Here we describe the role of Grb10 in FLT3‐ITD‐mediated AML. We observed that Grb10 physically associates with FLT3 in response to FLT3‐ligand (FL) st...

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Библиографические подробности
Опубликовано в: :Mol Oncol
Главные авторы: Kazi, Julhash U., Rönnstrand, Lars
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528487/
https://ncbi.nlm.nih.gov/pubmed/23246379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.11.003
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