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The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
Poly (ADP‐ribose) polymerase (PARP) inhibitors effectively kill tumours defective in the BRCA1 or BRCA2 genes through the concept of synthetic lethality. It is suggested that PARP inhibitors cause an increase in DNA single‐strand breaks (SSBs), which are converted during replication to irreparable t...
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| Pubblicato in: | Mol Oncol |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5528309/ https://ncbi.nlm.nih.gov/pubmed/21821475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2011.07.001 |
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