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Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor

The identification of the kinase or kinases targeted by protein kinase inhibitors is a critical challenge in validating their use as therapeutic agents or molecular probes. Here, to address this problem, we describe a chemical genomics strategy that uses a direct comparison between microarray transc...

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Detalhes bibliográficos
Main Authors: Kung, Charles, Kenski, Denise M., Dickerson, Scott H., Howson, Russell W., Kuyper, Lee F., Madhani, Hiten D., Shokat, Kevan M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC552777/
https://ncbi.nlm.nih.gov/pubmed/15738404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407170102
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