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An all-in-one UniSam vector system for efficient gene activation
We have generated a drug-free, all-in-one dCAS9-SAM vector that can activate endogenous gene expression with the potential to modify cell fate. We demonstrate that this strategy can be used in a number of cell lines and avoids exceptionally high levels of gene expression that are observed in standar...
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| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5526871/ https://ncbi.nlm.nih.gov/pubmed/28743878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06468-6 |
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