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SplitAx: A novel method to assess the function of engineered nucleases

Engineered nucleases have been used to generate knockout or reporter cell lines and a range of animal models for human disease. These new technologies also hold great promise for therapeutic genome editing. Current methods to evaluate the activity of these nucleases are time consuming, require exten...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Axton, Richard A., Haideri, Sharmin S., Lopez-Yrigoyen, Martha, Taylor, Helen A., Forrester, Lesley M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315338/
https://ncbi.nlm.nih.gov/pubmed/28212417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171698
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