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SplitAx: A novel method to assess the function of engineered nucleases

Engineered nucleases have been used to generate knockout or reporter cell lines and a range of animal models for human disease. These new technologies also hold great promise for therapeutic genome editing. Current methods to evaluate the activity of these nucleases are time consuming, require exten...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Axton, Richard A., Haideri, Sharmin S., Lopez-Yrigoyen, Martha, Taylor, Helen A., Forrester, Lesley M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315338/
https://ncbi.nlm.nih.gov/pubmed/28212417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171698
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