Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying

BACKGROUND & AIMS: Depletion of interstitial cells of Cajal (ICCs) is common in diabetic gastroparesis. However, in approximately 20% of patients with diabetes, gastric emptying (GE) is accelerated. GE is also faster in obese individuals, and is associated with increased blood levels of glucose...

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Udgivet i:Gastroenterology
Main Authors: Hayashi, Yujiro, Toyomasu, Yoshitaka, Saravanaperumal, Siva Arumugam, Bardsley, Michael R., Smestad, John A., Lorincz, Andrea, Eisenman, Seth T., Cipriani, Gianluca, Nelson Holte, Molly H., Al Khazal, Fatimah J., Syed, Sabriya A., Gajdos, Gabriella B., Choi, Kyoung Moo, Stoltz, Gary J., Miller, Katie E., Kendrick, Michael L., Rubin, Brian P., Gibbons, Simon J., Bharucha, Adil E., Linden, David R., Maher, Louis James, Farrugia, Gianrico, Ordog, Tamas
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526732/
https://ncbi.nlm.nih.gov/pubmed/28438610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.04.020
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