Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca(2+) transients and slow waves in adult mouse small intestine

Myenteric plexus interstitial cells of Cajal (ICC-MY) in the small intestine are Kit(+) electrical pacemakers that express the Ano1/TMEM16A Ca(2+)-activated Cl(–) channel, whose functions in the gastrointestinal tract remain incompletely understood. In this study, an inducible Cre-LoxP-based approac...

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Veröffentlicht in:Am J Physiol Gastrointest Liver Physiol
Hauptverfasser: Malysz, John, Gibbons, Simon J., Saravanaperumal, Siva A., Du, Peng, Eisenman, Seth T., Cao, Chike, Oh, Uhtaek, Saur, Dieter, Klein, Sabine, Ordog, Tamas, Farrugia, Gianrico
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401988/
https://ncbi.nlm.nih.gov/pubmed/27979828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00363.2016
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