Immunoreactivity for Ano1 Detects Depletion of Kit-positive Interstitial Cells of Cajal in Patients with Slow Transit Constipation

BACKGROUND AND AIMS: Depletion of interstitial cells of Cajal (ICC) is associated with several gastrointestinal motility disorders. Changes in ICC networks are usually detected by immunolabeling for the receptor tyrosine kinase Kit. Ano1 (DOG1 or TMEM16A) was recently described as a marker of ICC in...

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Bibliographic Details
Main Authors: Kashyap, Purna, Gomez-Pinilla, Pedro Julian, Pozo, Maria J., Cima, Robert R., Dozois, Eric J., Larson, David W., Ordog, Tamas, Gibbons, Simon J., Farrugia, Gianrico
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138829/
https://ncbi.nlm.nih.gov/pubmed/21585622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2982.2011.01729.x
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