Ano1, a Ca(2+)-activated Cl(−) channel, coordinates contractility in mouse intestine by Ca(2+) transient coordination between interstitial cells of Cajal

Interstitial cells of Cajal (ICC) are pacemaker cells that generate electrical activity to drive contractility in the gastrointestinal tract via ion channels. Ano1 (Tmem16a), a Ca(2+)-activated Cl(−) channel, is an ion channel expressed in ICC. Genetic deletion of Ano1 in mice resulted in loss of sl...

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Detalhes bibliográficos
Main Authors: Singh, Raman Deep, Gibbons, Simon J, Saravanaperumal, Siva Arumugam, Du, Peng, Hennig, Grant W, Eisenman, Seth T, Mazzone, Amelia, Hayashi, Yujiro, Cao, Chike, Stoltz, Gary J, Ordog, Tamas, Rock, Jason R, Harfe, Brian D, Szurszewski, Joseph H, Farrugia, Gianrico
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2014
Assuntos:
Alimentary
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198014/
https://ncbi.nlm.nih.gov/pubmed/25063822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.277152
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