Chaperonin-based biolayer interferometry to assess the kinetic stability of metastable, aggregation-prone proteins

Stabilizing the folded state of metastable and/or aggregation-prone proteins through exogenous ligand binding is an appealing strategy to decrease disease pathologies brought on by protein folding defects or deleterious kinetic transitions. Current methods of examining ligand binding to these margin...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Lea, Wendy A., Naik, Subhashchandra, Chaudhri, Tapan, Machen, Alexandra J., O’Neil, Pierce T., McGinn-Straub, Wesley, Tischer, Alexander, Auton, Matthew T., Burns, Joshua R., Baldwin, Michael R., Khar, Karen R., Karanicolas, John, Fisher, Mark T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524994/
https://ncbi.nlm.nih.gov/pubmed/27505032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00293
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