Chaperonin-based biolayer interferometry to assess the kinetic stability of metastable, aggregation-prone proteins

Stabilizing the folded state of metastable and/or aggregation-prone proteins through exogenous ligand binding is an appealing strategy to decrease disease pathologies brought on by protein folding defects or deleterious kinetic transitions. Current methods of examining ligand binding to these margin...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Lea, Wendy A., Naik, Subhashchandra, Chaudhri, Tapan, Machen, Alexandra J., O’Neil, Pierce T., McGinn-Straub, Wesley, Tischer, Alexander, Auton, Matthew T., Burns, Joshua R., Baldwin, Michael R., Khar, Karen R., Karanicolas, John, Fisher, Mark T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524994/
https://ncbi.nlm.nih.gov/pubmed/27505032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00293
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