Monitoring the kinetics of the pH driven transition of the anthrax toxin prepore to the pore by biolayer interferometry and surface plasmon resonance

Domain 2 of the anthrax protective antigen (PA) prepore heptamer unfolds and refolds during endosome acidification to generate an extended 100 Å beta barrel pore that inserts into the endosomal membrane. The PA pore facilitates the pH dependent unfolding and translocation of bound toxin enzymic comp...

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Hauptverfasser: Naik, Subhashchandra, Brock, Susan, Akkaladevi, Narahari, Tally, Jon, Mcginn-Straub, Wesley, Zhang, Na, Gao, Phillip, Gogol, E. P., Pentelute, B. L., Collier, R. John, Fisher, Mark T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790466/
https://ncbi.nlm.nih.gov/pubmed/23964683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400705n
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