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Optimization of the process of inverted peptides (PIPE(PLUS)) to screen PDZ domain ligands

PDZ domains play crucial roles in cell signaling processes and are therefore attractive targets for the development of therapeutic inhibitors. In many cases, C-terminal peptides are the physiological binding partners of PDZ domains. To identify both native ligands and potential inhibitors we thus ha...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Seisel, Quentin, Rädisch, Marisa, Gill, Nicholas P, Madden, Dean R, Boisguerin, Prisca
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523833/
https://ncbi.nlm.nih.gov/pubmed/28549735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.05.045
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