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Bivalent Peptides as PDZ Domain Ligands

A series of multivalent peptides with the ability to simultaneously bind two separate PDZ domain proteins has been designed, synthesized and tested by isothermal titration calorimetry (ITC). The monomer sequences, linked with succinate, varied in length from five to nine residues. The thermodynamic...

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Detalhes bibliográficos
Main Authors: Klosi, Edvin, Saro, Dorina, Spaller, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169291/
https://ncbi.nlm.nih.gov/pubmed/17890086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.09.035
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