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Bivalent Peptides as PDZ Domain Ligands

A series of multivalent peptides with the ability to simultaneously bind two separate PDZ domain proteins has been designed, synthesized and tested by isothermal titration calorimetry (ITC). The monomer sequences, linked with succinate, varied in length from five to nine residues. The thermodynamic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Klosi, Edvin, Saro, Dorina, Spaller, Mark R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169291/
https://ncbi.nlm.nih.gov/pubmed/17890086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.09.035
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