Computational Design of a PDZ Domain Peptide Inhibitor that Rescues CFTR Activity

The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial chloride channel mutated in patients with cystic fibrosis (CF). The most prevalent CFTR mutation, ΔF508, blocks folding in the endoplasmic reticulum. Recent work has shown that some ΔF508-CFTR channel activity can be rec...

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Bibliographic Details
Main Authors: Roberts, Kyle E., Cushing, Patrick R., Boisguerin, Prisca, Madden, Dean R., Donald, Bruce R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330111/
https://ncbi.nlm.nih.gov/pubmed/22532795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002477
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