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Identifying Stereochemical Preferences that Modulate Affinity and Selectivity among Five PDZ Domains that Bind CFTR: Comparative Crystallographic and Sequence Analyses
PDZ domain interactions are involved in signaling and trafficking pathways that coordinate crucial cellular processes. Alignment-based PDZ binding motifs identify the few most favorable residues at certain positions along the peptide backbone. However, sequences that bind the CAL (CFTR-Associated Li...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947174/ https://ncbi.nlm.nih.gov/pubmed/24210758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.019 |
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