Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma

High-grade glioma (HGG) is an incurable brain cancer. The transcriptomes of cells within HGG tumors are highly heterogeneous. This renders the tumors unresponsive or able to adapt to therapeutics targeted at single pathways, thereby causing treatment failure. To overcome this, we focused on cyclin-d...

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Publicat a:Oncogenesis
Autors principals: Greenall, S A, Lim, Y C, Mitchell, C B, Ensbey, K S, Stringer, B W, Wilding, A L, O'Neill, G M, McDonald, K L, Gough, D J, Day, B W, Johns, T G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523066/
https://ncbi.nlm.nih.gov/pubmed/28504693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.33
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