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Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma

High-grade glioma (HGG) is an incurable brain cancer. The transcriptomes of cells within HGG tumors are highly heterogeneous. This renders the tumors unresponsive or able to adapt to therapeutics targeted at single pathways, thereby causing treatment failure. To overcome this, we focused on cyclin-d...

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Bibliographic Details
Published in:Oncogenesis
Main Authors: Greenall, S A, Lim, Y C, Mitchell, C B, Ensbey, K S, Stringer, B W, Wilding, A L, O'Neill, G M, McDonald, K L, Gough, D J, Day, B W, Johns, T G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523066/
https://ncbi.nlm.nih.gov/pubmed/28504693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.33
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