Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma

High-grade glioma (HGG) is an incurable brain cancer. The transcriptomes of cells within HGG tumors are highly heterogeneous. This renders the tumors unresponsive or able to adapt to therapeutics targeted at single pathways, thereby causing treatment failure. To overcome this, we focused on cyclin-d...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Greenall, S A, Lim, Y C, Mitchell, C B, Ensbey, K S, Stringer, B W, Wilding, A L, O'Neill, G M, McDonald, K L, Gough, D J, Day, B W, Johns, T G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523066/
https://ncbi.nlm.nih.gov/pubmed/28504693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.33
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