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Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK pathway

Hypothalamic inflammation and increased oxidative stress are believed to be mechanisms that contribute to obesity. 4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (tempol), a free radical scavenger, has been shown to reduce inflammation and oxidative stress. We hypothesized that brain infusion of tem...

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Detalhes bibliográficos
Publicado no:Appl Physiol Nutr Metab
Main Authors: Toklu, Hale Z., Scarpace, Philip J., Sakarya, Yasemin, Kirichenko, Nataliya, Matheny, Michael, Bruce, Erin B., Carter, Christy S., Morgan, Drake, Tümer, Nihal
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522741/
https://ncbi.nlm.nih.gov/pubmed/28006433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1139/apnm-2016-0067
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