Rapamycin Normalizes Serum Leptin by Alleviating Obesity and Reducing Leptin Synthesis in Aged Rats

This investigation examines whether a low intermittent dose of rapamycin will avoid the hyperlipidemia and diabetes-like syndrome associated with rapamycin while still decreasing body weight and adiposity in aged obese rats. Furthermore, we examined if the rapamycin-mediated decrease in serum leptin...

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Pubblicato in:J Gerontol A Biol Sci Med Sci
Autori principali: Scarpace, Philip J., Matheny, Michael, Strehler, Kevin Y.E., Toklu, Hale Zerrin, Kirichenko, Nataliya, Carter, Christy S., Morgan, Drake, Tümer, Nihal
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906318/
https://ncbi.nlm.nih.gov/pubmed/25617379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glu230
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