Cholangiocytes act as Facultative Liver Stem Cells during Impaired Hepatocyte Regeneration

Following liver injury, regeneration occurs through self-replication of hepatocytes. In severe liver injury, hepatocyte proliferation is impaired, a feature of human chronic liver disease1,2. It is contested whether other liver cell types can regenerate hepatocytes3–5. Here, we use two independent s...

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Pubblicato in:Nature
Autori principali: Raven, Alexander, Lu, Wei-Yu, Man, Tak Yung, Ferreira-Gonzalez, Sofia, O’Duibhir, Eoghan, Dwyer, Benjamin J, Thomson, John P, Meehan, Richard R, Bogorad, Roman, Koteliansky, Victor, Kotelevtsev, Yuri, ffrench-Constant, Charles, Boulter, Luke, Forbes, Stuart J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522613/
https://ncbi.nlm.nih.gov/pubmed/28700576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23015
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