Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

Cellular senescence is a mechanism that provides an irreversible barrier to cell cycle progression to prevent undesired proliferation. However, under pathological circumstances, senescence can adversely affect organ function, viability and regeneration. We have developed a mouse model of biliary sen...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ferreira-Gonzalez, Sofia, Lu, Wei-Yu, Raven, Alexander, Dwyer, Benjamin, Man, Tak Yung, O’Duibhir, Eoghan, Lewis, Philip J. Starkey, Campana, Lara, Kendall, Tim J., Bird, Thomas G., Tarrats, Nuria, Acosta, Juan-Carlos, Boulter, Luke, Forbes, Stuart J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844882/
https://ncbi.nlm.nih.gov/pubmed/29523787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03299-5
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