Hepatic progenitor cells of biliary origin with liver repopulation capacity

Hepatocytes and cholangiocytes self renew following liver injury. Following severe injury hepatocytes are increasingly senescent, whether Hepatic Progenitor Cells (HPCs) then contribute to liver regeneration is unclear. Here, we describe a mouse model where Mdm2 is inducibly deleted in over 98% of h...

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Bibliographic Details
Published in:Nat Cell Biol
Main Authors: Lu, Wei-Yu, Bird, Thomas G, Boulter, Luke, Tsuchiya, Atsunori, Cole, Alicia M, Hay, Trevor, Guest, Rachel V, Wojtacha, Davina, Man, Tak Yung, Mackinnon, Alison, Ridgway, Rachel A, Kendall, Timothy, Williams, Michael J, Jamieson, Thomas, Raven, Alex, Hay, David C, Iredale, John P, Clarke, Alan R, Sansom, Owen J, Forbes, Stuart J
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612439/
https://ncbi.nlm.nih.gov/pubmed/26192438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3203
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