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Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines

Anthracyclines are key components of human breast cancer chemotherapy. Here, we explored the role of Akt signaling in anthracycline resistance. The antitumor activity of doxorubicin and Akt inhibitor A-443654 alone or combined was examined in estrogen receptor (ER) positive and negative human breast...

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Pubblicato in:Oncotarget
Autori principali: Yndestad, Synnøve, Austreid, Eilin, Svanberg, Ida R., Knappskog, Stian, Lønning, Per E., Eikesdal, Hans P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522318/
https://ncbi.nlm.nih.gov/pubmed/28476032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17167
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