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Constitutional Mosaic Epimutations - a hidden cause of cancer?

Silencing of tumor suppressor genes by promoter hypermethylation is a key mechanism to facilitate cancer progression in many malignancies. While promoter hypermethylation can occur at later stages of the carcinogenesis process, constitutional methylation of key tumor suppressors may be an initiating...

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Detalhes bibliográficos
Publicado no:Cell Stress
Main Authors: Lønning, Per E., Eikesdal, Hans P., Løes, Inger M., Knappskog, Stian
Formato: Artigo
Idioma:Inglês
Publicado em: Shared Science Publishers OG 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551830/
https://ncbi.nlm.nih.gov/pubmed/31225507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/cst2019.04.183
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