The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

Phospholipase C-gamma (PLC-gamma) and GTPase activating protein (GAP) are substrates of EGF, PDGF and other growth factor receptors. Since either PLC-gamma or GAP also bind to the activated receptors it was suggested that their SH2 domains are mediating this association. We attempted to delineate th...

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Publicado en:EMBO J
Autores principales: Margolis, B, Li, N, Koch, A, Mohammadi, M, Hurwitz, D R, Zilberstein, A, Ullrich, A, Pawson, T, Schlessinger, J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC552227/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2176151/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1990.tb07887.x
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