The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

Phospholipase C-gamma (PLC-gamma) and GTPase activating protein (GAP) are substrates of EGF, PDGF and other growth factor receptors. Since either PLC-gamma or GAP also bind to the activated receptors it was suggested that their SH2 domains are mediating this association. We attempted to delineate th...

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Detalhes bibliográficos
Main Authors: Margolis, B, Li, N, Koch, A, Mohammadi, M, Hurwitz, D R, Zilberstein, A, Ullrich, A, Pawson, T, Schlessinger, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC552227/
https://ncbi.nlm.nih.gov/pubmed/2176151
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