Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

SN-38, the active metabolite of irinotecan, and histone deacetylase inhibitors (HDACis) such as belinostat, vorinostat and panobinostat, have all been shown to be deactivated by glucuronidation via UGTs. Since they all compete for UGTs for deactivation, we aimed to investigate the inhibitory effect...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Wang, Lingzhi, Linus Chan, Chong En, Wong, Andrea Li-Ann, Wong, Fang Cheng, Lim, Siew Woon, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Lee, Lawrence Soon-U, Soo, Ross, Yong, Wei Peng, Lee, Soo Chin, Ho, Paul Chi-Lui, Sethi, Gautam, Goh, Boon Cher
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2017
Konular:
Clinical Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522258/
https://ncbi.nlm.nih.gov/pubmed/28157715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15017
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