Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients

Belinostat is a hydroxamate class HDAC inhibitor that has demonstrated activity in peripheral T-cell lymphoma and is undergoing clinical trials for non-hematologic malignancies. We studied the pharmacokinetics of belinostat in hepatocellular carcinoma patients to determine the main pathway of metabo...

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Detalhes bibliográficos
Main Authors: Wang, Ling-Zhi, Ramírez, Jacqueline, Yeo, Winnie, Chan, Mei-Yi Michelle, Thuya, Win-Lwin, Lau, Jie-Ying Amelia, Wan, Seow-Ching, Wong, Andrea Li-Ann, Zee, Ying-Kiat, Lim, Robert, Lee, Soo-Chin, Ho, Paul C., Lee, How-Sung, Chan, Anthony, Ansher, Sherry, Ratain, Mark J., Goh, Boon-Cher
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559838/
https://ncbi.nlm.nih.gov/pubmed/23382909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054522
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