Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

SN-38, the active metabolite of irinotecan, and histone deacetylase inhibitors (HDACis) such as belinostat, vorinostat and panobinostat, have all been shown to be deactivated by glucuronidation via UGTs. Since they all compete for UGTs for deactivation, we aimed to investigate the inhibitory effect...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Wang, Lingzhi, Linus Chan, Chong En, Wong, Andrea Li-Ann, Wong, Fang Cheng, Lim, Siew Woon, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Lee, Lawrence Soon-U, Soo, Ross, Yong, Wei Peng, Lee, Soo Chin, Ho, Paul Chi-Lui, Sethi, Gautam, Goh, Boon Cher
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
Assuntos:
Clinical Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522258/
https://ncbi.nlm.nih.gov/pubmed/28157715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15017
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