Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

SN-38, the active metabolite of irinotecan, and histone deacetylase inhibitors (HDACis) such as belinostat, vorinostat and panobinostat, have all been shown to be deactivated by glucuronidation via UGTs. Since they all compete for UGTs for deactivation, we aimed to investigate the inhibitory effect...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Wang, Lingzhi, Linus Chan, Chong En, Wong, Andrea Li-Ann, Wong, Fang Cheng, Lim, Siew Woon, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Lee, Lawrence Soon-U, Soo, Ross, Yong, Wei Peng, Lee, Soo Chin, Ho, Paul Chi-Lui, Sethi, Gautam, Goh, Boon Cher
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Clinical Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522258/
https://ncbi.nlm.nih.gov/pubmed/28157715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15017
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires