Phenotyping of UGT1A1 Activity Using Raltegravir Predicts Pharmacokinetics and Toxicity of Irinotecan in FOLFIRI

BACKGROUND: Irinotecan toxicity correlates with UGT1A1 activity. We explored whether phenotyping UGT1A1 using a probe approach works better than current genotyping methods. METHODS: Twenty-four Asian cancer patients received irinotecan as part of the FOLFIRI regimen. Subjects took raltegravir 400 mg...

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Pubblicato in:PLoS One
Autori principali: Lee, Lawrence Soon-U, Seng, Kok-Yong, Wang, Ling-Zhi, Yong, Wei-Peng, Hee, Kim-Hor, Soh, Thomas I., Wong, Andrea, Cheong, Pei F., Soong, Richie, Sapari, Nur S., Soo, Ross, Fan, Lu, Lee, Soo-Chin, Goh, Boon C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726617/
https://ncbi.nlm.nih.gov/pubmed/26808671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147681
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