Pharmacokinetic Modeling of Plasma and Intracellular Concentrations of Raltegravir in Healthy Volunteers

Raltegravir is a potent inhibitor of HIV integrase. Persistently high intracellular concentrations of raltegravir may explain sustained efficacy despite high pharmacokinetic variability. We performed a pharmacokinetic study of healthy volunteers. Paired blood samples for plasma and peripheral blood...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Lingzhi, Soon, Gaik Hong, Seng, Kok-Yong, Li, Jun, Lee, Edmund, Yong, Eu-Leong, Goh, Boon-Cher, Flexner, Charles, Lee, Lawrence
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2011
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165315/
https://ncbi.nlm.nih.gov/pubmed/21746959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00593-11
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