Population Pharmacokinetic Analysis of Isoniazid, Acetylisoniazid, and Isonicotinic Acid in Healthy Volunteers

In this study, we aimed to quantify the effects of the N-acetyltransferase 2 (NAT2) phenotype on isoniazid (INH) metabolism in vivo and identify other sources of pharmacokinetic variability following single-dose administration in healthy Asian adults. The concentrations of INH and its metabolites ac...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Seng, Kok-Yong, Hee, Kim-Hor, Soon, Gaik-Hong, Chew, Nicholas, Khoo, Saye H., Lee, Lawrence Soon-U
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604378/
https://ncbi.nlm.nih.gov/pubmed/26282412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01244-15
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